5-Amino-1MQ

5-Amino-1MQ (5-amino-1-methylquinolinium iodide) is a synthetic small-molecule research compound characterized as a selective inhibitor of nicotinamide N-methyltransferase (NNMT). It is widely utilized in metabolic and cellular energy research focused on nicotinamide metabolism, methylation balance, and NAD⁺-regulated pathways.

Product Information

• Chemical Name: 5-Amino-1-methylquinolinium iodide
• Common Name: 5-Amino-1MQ
• CAS Number: 42464-96-0
• Molecular Formula: C₁₀H₁₁N₂I
• Molecular Weight: 286.11 g/mol
• Synonyms: 5-amino-1-methylquinolinium; 5-Amino-1-MQ iodide; 1-methylquinolin-1-ium-5-amine
• Purity: ≥ 98–99% (HPLC) – typical research grade specification
• Appearance: Red tint liquid
• Storage Conditions: Store at -20°C in a dry, cool environment, protected from light and moisture; keep container tightly closed.

Research Profile

5-Amino-1MQ acts as a small-molecule NNMT inhibitor, blocking the methylation of nicotinamide and thereby modulating methyl donor utilization and downstream NAD⁺-related pathways. In preclinical models, NNMT inhibition by 5-Amino-1MQ has been associated with increased NAD⁺ availability, alterations in energy expenditure, and support of investigations into obesity, adipose tissue metabolism, and cellular energy balance.

This compound is suitable for in vitro and in vivo experimental systems studying NNMT biology, nicotinamide and methylation dynamics, and the regulation of metabolic signaling networks. Researchers commonly employ 5-Amino-1MQ as a tool compound to explore NNMT-dependent mechanisms, redox balance, and related epigenetic and metabolic endpoints.

Formulation and Solubility

• Solubility (in vitro): Soluble in DMSO; solubility may vary with solvent, temperature, and concentration.
• Suggested Solvents: DMSO for concentrated stock solutions, with further dilution into appropriate aqueous buffers or vehicles compatible with the assay system.
• Handling: Allow vial to reach room temperature before opening, minimize exposure to air and moisture, and avoid repeated freeze–thaw cycles by preparing single-use aliquots when possible.

Intended Use

This material is supplied for laboratory research use only and is not intended for human or veterinary use, clinical applications, diagnostic procedures, or household purposes. All handling and disposal should follow appropriate laboratory safety guidelines and institutional regulations for chemical research materials.