MOTS-C (Research Use Only)
Chemical Name: MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c)
CAS Number:
1627580-64-6
Molecular Formula:
C101H152N28O22S2
Molecular Weight: 2174.6 g/mol
Sequence: H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH
Appearance: White to off-white lyophilized powder
Storage: Store at −20°C for long-term stability
Form: Lyophilized solid; soluble in water or DMSO
Description
MOTS-c is a 16-amino acid mitochondrial-derived peptide that plays a key role in regulating cellular metabolism, energy homeostasis, and stress response. It is involved in promoting metabolic flexibility by activating AMP-activated protein kinase (AMPK), enhancing glucose metabolism and improving insulin sensitivity. MOTS-c has been shown in research to support mitochondrial function, metabolic health, and longevity.
(Wikipedia)
(PubChem)
Research Applications
- Metabolic regulation and improvement of insulin sensitivity
- Studies on mitochondrial function and cellular energy homeostasis
- Investigation of anti-inflammatory and anti-aging effects
- Bone metabolism and support for osteoporosis models
- Potential protective effects against metabolic and inflammatory diseases
Key Research & Reports
Mechanism of Action
MOTS-c activates AMP-activated protein kinase (AMPK), a key regulator of cellular energy balance. This activation promotes increased glucose uptake and utilization, enhanced lipid metabolism, and reduced inflammation, thereby improving metabolic health and resilience to stress at the cellular level.
(Selleck Chemicals)
Safety and Handling
Store lyophilized MOTS-c peptide at −20°C to maintain stability. Reconstitute in sterile water or DMSO immediately before use. Limited reports describe mild injection site irritation; overall, MOTS-c demonstrates a favorable safety profile in research studies.
Disclaimer
For laboratory research use only. Not for human consumption, medical, veterinary, or diagnostic use. Provided information is for academic and research purposes
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