Thymosin Alpha-1 (Research Use Only)
Chemical Name: Thymosin Alpha-1 (Thymalfasin)
CAS Number:
62304-98-7
Molecular Formula: C129H215N33O55
Molecular Weight: 3108.28 g/mol
Sequence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH
Appearance: White to off-white sterile lyophilized powder
Storage: Store at −20°C in a dry place, protected from light
Form: Lyophilized peptide powder; soluble in water or sterile buffer
Description
Thymosin Alpha-1 is a synthetic 28-amino acid peptide closely related to the thymic hormone involved in the regulation and enhancement of immune function. It is studied for its immunomodulatory properties, including stimulation of T-cell and dendritic cell responses, enhancement of cytokine production, and protective effects against infections and cancer. Thymosin Alpha-1 has demonstrated potential in reducing toxicity from chemotherapy and supporting immune reconstitution in immunocompromised models.
(Wikipedia)
(PubChem)
Research Applications
- Immune system enhancement and immunomodulation
- Support in infectious disease and viral models
- Reduction of chemotherapy-induced toxicity
- Potential treatment for cancers and chronic infections
- Studies on T-cell activation and cytokine regulation
Key References
Mechanism of Action
Thymosin Alpha-1 enhances immune response by modulating T-lymphocyte function, dendritic cell maturation, and cytokine expression. It promotes immune surveillance and repair processes, contributing to its antiviral, anticancer, and immunoregulatory effects.
Safety and Handling
Store lyophilized Thymosin Alpha-1 powder at −20°C, protected from moisture and light. Reconstitute in sterile water or buffer immediately before use. Preclinical and clinical data report a favorable safety and tolerability profile.
Disclaimer
For laboratory research use only. Not for human, veterinary, medical, or diagnostic use. Provided strictly for scientific and educational research.
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