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ETH-R3 20MG

$57.12

Category: Cellular Aging Research

Description
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Retatrutide (Research Use Only)

Chemical Name: Retatrutide (LY-3437943)

CAS Number:
2381089-83-2

Molecular Formula:
C₂₂₁H₃₄₂N₄₆O₆₈

Molecular Weight: 4731.33 g/mol

Sequence: Tyr-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{MeLeu}-Leu-Asp-Lys-{diacidC20γGlu(AEEA)Lys}-Ala-Gln-{Aib}-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH₂ (Sodium salt)

Appearance: White lyophilized powder

Storage: Store at −20°C for long-term stability

Form: Powder, soluble in water and DMSO

Description

Retatrutide is a synthetic 39-amino acid peptide that functions as a potent triple agonist targeting glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors. It exhibits strong glucose-lowering effects and promotes substantial weight loss through integrated modulation of these key metabolic pathways. Retatrutide’s unique activity profile includes delayed gastric emptying, reduced food intake, and improved insulin secretion and sensitivity.
(Wikipedia)
(DrugBank)

Research Applications

Obesity and metabolic disorder studies focusing on multi-receptor agonism
Investigation into glycemic control and insulin secretion enhancement
Preclinical and clinical evaluation of weight reduction and appetite modulation
Studies on cardiovascular and metabolic benefits of triple receptor activation

Key Research & Reports

Mechanism of Action

Retatrutide activates three hormone receptors: GLP-1, GIP, and glucagon receptors. This triagonism induces enhanced insulin secretion in a glucose-dependent manner, suppresses glucagon release, delays gastric emptying, and reduces appetite. Together, these effects promote significant weight loss and improved metabolic outcomes in research models.
(DrugBank)

Safety and Handling

Store the lyophilized Retatrutide peptide powder at −20°C. Reconstitute in sterile water or appropriate solvent immediately prior to use in research assays. Retatrutide exhibits a well-tolerated safety profile with mild gastrointestinal effects reported in model organisms.

Disclaimer

For laboratory research use only. Not for human, medical, veterinary, or diagnostic purposes. Product information provided solely for academic, research, and educational contexts.